ANTIANGIOGENIC ACTIVITY AND ROS-MEDIATED LUNG CANCER CELL LINE INJURY OF ZERUMBONE

Objective: Zerumbone (ZER) is a well-known natural compound that has been reported to have anti-cancer effect. Thus, this study investigated the ZER potential inhibit Thymidine Phosphorylase (TP) and ability trigger Reactive oxygen species (ROS)-mediated cytotoxicity in non-small cell lung cancer, NCI-H460, line. Material Method: The antiangiogenic activity for was evaluated by using thymidine phosphorylase inhibitory test. (ROS) production determined via DCFDA dye flow cytometry. Result Discussion: found be potent TP with IC50 value of 50.3± 0.31 μg/ml or 230±1.42 µM. NCI-H460 cells upon treatment produced significant ROS 55.7%. Consequently, exerts anti-angiogenic properties modulates cancer cells, serving as leads better therapeutic index drug.